Pax proteins in embryogenesis and their role in nervous system development

Aimar Namm, Andres Arend, Marina Aunapuu

Abstract


The mammalian Pax genes encode a family of transcription factors, which play important roles in embryonic development and organogenesis. During the central nervous system development Pax genes have substantial roles in neural differentiation and regional specification. Pax proteins are expressed in populations of nerve cells within the developing forebrain, midbrain, hindbrain and spinal cord. In this article the fundamental roles of Pax proteins in the embryogenesis are outlined and the temporal and spatial influences of Pax on the formation of the central nervous system are discussed.

Keywords


human embryos; Pax; brain; spinal cord

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DOI: https://doi.org/10.12697/poa.2013.22.14

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ISSN 1406-0140 (print)
ISSN 1736-7646 (online)
Journal DOI: http://dx.doi.org/10.12697/issn1406-0140