Expression of LHCG receptor in the mouse vulva

Authors

  • Helen Zirnask Department of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  • Pasi Pöllänen Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland
  • Epp Kotter Department of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  • Siim Suutre Department of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  • Eliis Grigor Department of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  • Kersti Kokk Department of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia https://orcid.org/0009-0004-2357-0628

DOI:

https://doi.org/10.12697/poa.2024.33.2.03

Keywords:

luteinizing hormone, luteinizing hormone receptor, vulva

Abstract

The elevated serum LHCG concentrations have been detected between 40 and 70 years both in male and female. In previous studies LHCG receptor was detected in the mouse and human penis both in corpus cavernosum penis and corpus spongiosum penis. There is no information about the expression of LHCG receptor in the vulva up to now. The aim of present study is to investigate the expression of the LHCG receptor in the mouse vulva tissue to see, if the LH effects can be possible in vulva.

12 Balb/c mice (7–8 weeks old) were used as donors of normal vulva tissue. Immunohistochemistry was used for the detection of the LHCG receptor.

Positive immunoreaction for LHCG receptors was detected in the epithelial cells in all layers of the mouse vulva epithelium, in the epithelial cells of the gland ducts and in the interstitial cells of subepithelial connective tissue.

The high postmenopausal gonadotrophin concentrations could have direct effects on the vulvar tissue, if there are receptors for them. LHCG receptors were detected in the different cell types in the mouse vulva. It could be possible that the higher serum LH concentrations both in aging male and female could have direct effects on the spongious tissue both in the individual and his/her partner. Further studies are indicated.

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Published

2024-12-31

Issue

Vol. 33 No. 2 (2024)

Section

Articles