https://ojs.utlib.ee/index.php/SJLAS/issue/feed 2025-04-08T12:24:28+00:00 Klas Abelson klasab@sund.ku.dk Open Journal Systems <p>Published by the Scandinavian Society for Laboratory Animal Science, Sweden</p> <p>Online ISSN <strong>2002-0112</strong></p> https://ojs.utlib.ee/index.php/SJLAS/article/view/24006 2024-06-03T10:33:17+00:00 Masahiro Morimoto morimasa@yamaguchi-u.ac.jp Yusuke Yamada b014tnv@yamaguchi-u.ac.jp Keisuke Okamoto k-mol@i.softbank.jp Saya Kagimoto s-kagimoto74407@pref.hiroshima.lg.jp Masashi Sakurai sakurai@yamaguchi-u.ac.jp Yusuke Sakai sakaiyu@nih.go.jp Moe Hasegawa m_hasegawa@vetmed.hokudai.ac.jp Hiroyuki Imai himai@yamaguchi-u.ac.jp Shusaku Shibutani shushibu@yamaguchi-u.ac.jp

<p>Eosinophilia is a pathological condition characterized by increased eosinophils in tissues and peripheral blood. The type 2 immune response causes eosinophilia, and interleukin-5 (IL-5) secreted by T helper 2 (Th2) cells is essential for increasing eosinophils. However, it is unclear whether there is another mechanism for the increase in eosinophil other than IL-5 upregulation.</p> <p>The present study found high eosinophils in the ICR mice and established inbred mice with hypereosinophilia, named “Yama mouse”, through brother-sister mating.</p> <p>The eosinophils in the peripheral blood of 6-week-old Yama mice were 30-fold higher than those in ICR mice, and Yama mice did not have visible lesions. The IL-5 expression had no significant difference in the spleen, mesenteric lymph nodes, or bone marrow of ICR and Yama mice.</p> <p>Yama mice revealed a mechanism for increased eosinophil counts other than that of IL-5 upregulation. Yama mice exhibit eosinophilia without artificial treatment; therefore, they are a good animal model for studying allergic diseases and regenerative medicine, in which eosinophils are important.</p>

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