Scandinavian Journal of Laboratory Animal Science 2024-02-22T12:33:32+00:00 Hanna-Marja Voipio Open Journal Systems <p>Published by the Scandinavian Society for Laboratory Animal Science, Sweden</p> <p>Online ISSN <strong>2002-0112</strong></p> Focus on novel approaches: Home-cage monitoring of laboratory mice 2024-02-22T12:33:32+00:00 Aleksandra Bartelik not@known.nk Maša Čater not@known.nk Özge Selin Cevik not@known.nk Nuno Henrique Franco not@known.nk Vootele Voikar <p>Assessment of behavioural phenotype is crucial for the evaluation of various disease models, particularly in<br>laboratory rodents. Traditionally, this includes performing a variety of conventional tests where animals are<br>removed from their home-cages and placed in behavioural test apparatuses. This approach can be affected by<br>micro-environmental stress (removal from cage, handling, moving to an unfamiliar setting, and the test itself)<br>and other biases by capturing animals’ responses in a short time-window and potentially missing subtle or circadian<br>effects. Overall, serious concerns have been expressed regarding the validity and reliability of such measurements.<br>To address some of these concerns, researchers are increasingly resorting to automated home-cage monitoring<br>(HCM) technologies, which allow continuous recording of behavioural and physiological parameters of<br>undisturbed animals. In 2021, a pan-European network of researchers started the 4-year COST Action “Improving<br>biomedical research by automated behaviour monitoring in the animal home-cage” (CA20135 TEATIME,<br> For this project, experts from different fields joined forces to critically assess the<br>potential of available technologies, to develop guidelines and identify where further technological development is<br>needed, including analysis of big data. The opportunities opened by HCM for daily health and welfare monitoring<br>of laboratory mice in a contactless, stress-free, and continuous fashion are also being explored. We provide<br>a short overview of the progress made by the Action during the first year and a half (presentation available at<br></p> 2024-02-22T00:00:00+00:00 Copyright (c) 2024 Scandinavian Journal of Laboratory Animal Science