T cell Receptor αβ Transgenic Mice in Immunological Research

Abstract

T cell receptor transgenic mice have had an increasingly large impact on immunological research for the last 8 years during which such mice have been available. The mice have been important to further our understanding of T cell receptor acquisition and thymocyte development. In the coming years, it is anticipated that the mice will contribute to our apprehension of peripheral T cell activation and differentiation, and to the role of T cells in disease states.