Cell Ablation in Transgenic Mice

Abstract

The toxigcne approach. in which the toxic gene product is guided by the cell specific promoter to the desired tissue. is an effective way of ablating cells both in germline transgenic mice and also in somatic transgenic tissues. It opens up new possibilities for physiological and cell lineage studies and gene therapy of tumors. The more effective targeting of toxigcnes into the genome and timing of their expression will further increase their applicability.