Dynamics of cell population structure in liver biopsy of the patients with chronic hepatitis viral infection

  • Ivan I. Tokin St. Petersburg Medical Academy, Russia
  • Ivan B. Tokin St. Petersburg State University, Russia
  • Galina Filimonova St. Petersburg State University, Russia
  • Piret Hussar Institute of Anatomy, University of Tartu, Estonia
Keywords: liver biopsy, chronic viral hepatitis, morphometric analysis, caryometric analysis


The cell population analysis of liver biopsies from the patients with both chronic hepatitis, chronic viral hepatitis C (HCV) and chronic viral hepatitis B (HBV) included the comparative evaluation of the specific part of non-parenchymal elements, analysis of the liver plates and sinusoids areas, the cell population of liver plates and sinusoids, the caryometric description of different types of cells. The essential difference of similar quantitative indexes in the biopsy specimens of patients with HCV and НВV was revealed and discussed. In total, the quantitative analysis of cell population structure in liver biopsies during the course of chronic hepatitis, especially in the case of defective biopsies, could be used for diagnostics and prognoses by expert evaluation.


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