Two Intranasal Administration Techniques Give Two Different Pharmacokinetic Results


  • Sveinbjörn Gizurarson University of Iceland, Faculty of Pharmacy, Reykjavik
  • Erik Bechgaard The Royal Danish School of Pharmacy, Department of Pharmacy, Copenhagen
  • Rolf K Hjortkjær Ferring Pharmaceuticals, Copenhagen



Minor changes in the administration technique used for intranasal instillation of clonazepam, have been  found to influence the results significantly. A simple study was performed, where rabbits received 0.5 mg  clonazepam intranasally. One group received the drug while fixed in a sitting position, where the other  group was fixed in a supine position. The results show that both techniques where able to provide a rapid  absorption with a tmax around 3-4 min. The Cmax and AUC, however, were very different. The Cmax was found  to be 40 ng/ml and 86 ng/ml, respectively, and the AUC was found to be 891 and 2249 (ng/ml/min), respectively,  for the sitting and the supine position. The relative bioavailability for sitting/supine was found to be  38%. These results show that the administration technique is very important and should not be underestimated. 


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How to Cite

Gizurarson, S., Bechgaard, E., & Hjortkjær, R. K. (2006). Two Intranasal Administration Techniques Give Two Different Pharmacokinetic Results. Scandinavian Journal of Laboratory Animal Science, 33(1), 35–38.