Effect of Strontium Ranelate on Femur Densitometry and Antioxidative/Oxidative Status in Castrated Male Rats

Abstract

The studies were aimed at determinatning of the effect of strontium ranelate (SR) on the mineralization  processes and selected parameters of oxidative stress in orchidectomized rats during the development of  osteopenia. Male Wistar rats were sham-operated (SHO) and orchidectomized (ORX). ORX animals were  divided into control (ORX-C) and gavaged with SR (ORX-SR), at a dose of 900mg/kg/b.w. After 60 days  the animals were scanned for determination of bone mineral density (BMD) of the whole skeleton. Isolated  femora were examined by DEXA and pQCT. Tomographic measurements were performed for a total  slice and separately for the cortical and trabecular parts of the distal end of the femora. The intensity of  lipid peroxidation (ILP) and total antioxidant capacity (TAC) in blood serum were measured. SR treatment  increased vBMD and BMC of total, trabecular and cortical bone in ORX rats compared to ORX-C and  SHO rats. ORX significantly increased TAC in control animals, and SR limited this increase. ILP in SHO  and ORX-C rats which on a similar level. SR increased ILP by 21.3%, as compared to SHO. SR improved  densitometric and geometric parameters of femora by orchidectomized rats what prevented degradation of  bone tissue. Beneficial effects of SR were also demonstrated in stabilization of TAC in ORX rats at the level  noted in SHO rats.