Effect of Strontium Ranelate on Femur Densitometry and Antioxidative/Oxidative Status in Castrated Male Rats
The studies were aimed at determinatning of the effect of strontium ranelate (SR) on the mineralization processes and selected parameters of oxidative stress in orchidectomized rats during the development of osteopenia. Male Wistar rats were sham-operated (SHO) and orchidectomized (ORX). ORX animals were divided into control (ORX-C) and gavaged with SR (ORX-SR), at a dose of 900mg/kg/b.w. After 60 days the animals were scanned for determination of bone mineral density (BMD) of the whole skeleton. Isolated femora were examined by DEXA and pQCT. Tomographic measurements were performed for a total slice and separately for the cortical and trabecular parts of the distal end of the femora. The intensity of lipid peroxidation (ILP) and total antioxidant capacity (TAC) in blood serum were measured. SR treatment increased vBMD and BMC of total, trabecular and cortical bone in ORX rats compared to ORX-C and SHO rats. ORX significantly increased TAC in control animals, and SR limited this increase. ILP in SHO and ORX-C rats which on a similar level. SR increased ILP by 21.3%, as compared to SHO. SR improved densitometric and geometric parameters of femora by orchidectomized rats what prevented degradation of bone tissue. Beneficial effects of SR were also demonstrated in stabilization of TAC in ORX rats at the level noted in SHO rats.