Kinetics and Penetration into Inflammatory Tissue Cage Fluid of Cefepime Administered to Rabbits

Abstract

The kinetics and penetration of cefepime into inflammatory tissue cage fluid were determined in rabbits.  Ten adult healthy rabbits were used. Concentrations of cefepime were measured in serum and induced  inflammatory exudate by biological methods. The kinetic analysis was performed by mean of a non-compartmental  model. Pharmacokinetic results in serum (S) and inflammatory tissue cage fluid (ITCF) (means  ± standard error) were: half life of elimination [t1\2 (S) ]= 1.6 ± 0.2 and (ITCF) 3.7 ± 0.3 h; area under the  curve [AUC (S)]= 225.3 ± 21.4 and (ITCF) 208.0 ± 13.6 (μg/ml/h]; maximum concentration [Cmax (ITCF)]=  37.7 ± 3.6 μg/ml and time to reach Cmax [tmax (ITCF)]= 1.8 ± 0.4 h and the penetration into inflammatory  tissue cage fluid [P (ITCF)] = 92.3 ± 8.7 %. In conclusion, the cefepime administered to rabbits penetrate  rapidly and nearly completely into inflammatory tissue cage fluid.