Kinetics and Penetration into Inflammatory Tissue Cage Fluid of Cefepime Administered to Rabbits
The kinetics and penetration of cefepime into inflammatory tissue cage fluid were determined in rabbits. Ten adult healthy rabbits were used. Concentrations of cefepime were measured in serum and induced inflammatory exudate by biological methods. The kinetic analysis was performed by mean of a non-compartmental model. Pharmacokinetic results in serum (S) and inflammatory tissue cage fluid (ITCF) (means ± standard error) were: half life of elimination [t1\2 (S) ]= 1.6 ± 0.2 and (ITCF) 3.7 ± 0.3 h; area under the curve [AUC (S)]= 225.3 ± 21.4 and (ITCF) 208.0 ± 13.6 (μg/ml/h]; maximum concentration [Cmax (ITCF)]= 37.7 ± 3.6 μg/ml and time to reach Cmax [tmax (ITCF)]= 1.8 ± 0.4 h and the penetration into inflammatory tissue cage fluid [P (ITCF)] = 92.3 ± 8.7 %. In conclusion, the cefepime administered to rabbits penetrate rapidly and nearly completely into inflammatory tissue cage fluid.