Experimental model for CAPD studies in the rabbit

Abstract

An animal model suitable for bioeompatibility studies of peritoneal dialysis solutions is presented. It permits fluid exchanges to be performed 3 times a day for at least 28 days. thus simulating Continuous Ambulatory Peritoneal Dialysis (CAPD) in humans.
The surgical procedure is lenient, without omentectomy and nephrectomy. A closed, subcutaneous placed eatheter-system permits the animals to thrive well and move freely between dialysis-fluid exchanges. A Y-shaped dialysis equipment which
prevents air- and over-infusion was developed and is presented.
The surgical procedure and the implanted catheter caused only minor histological changes of the peritoneum. No catheter-tunnel infections were observed.
Our findings suggest that a slight peritoneal irritation is caused by the C:\PD-solutions, as non-infected, dialysed animals had a slightly higher body-temperature than controls and as the LD content of the dialysate was high probably indicating
cell-lysis.
Though peritonitis was not avoided this experimental model using rabbits was found suitable for long term CAPD studies.