Experimental model for CAPD studies in the rabbit
An animal model suitable for bioeompatibility studies of peritoneal dialysis solutions is presented. It permits fluid exchanges to be performed 3 times a day for at least 28 days. thus simulating Continuous Ambulatory Peritoneal Dialysis (CAPD) in humans.
The surgical procedure is lenient, without omentectomy and nephrectomy. A closed, subcutaneous placed eatheter-system permits the animals to thrive well and move freely between dialysis-fluid exchanges. A Y-shaped dialysis equipment which
prevents air- and over-infusion was developed and is presented.
The surgical procedure and the implanted catheter caused only minor histological changes of the peritoneum. No catheter-tunnel infections were observed.
Our findings suggest that a slight peritoneal irritation is caused by the C:\PD-solutions, as non-infected, dialysed animals had a slightly higher body-temperature than controls and as the LD content of the dialysate was high probably indicating
Though peritonitis was not avoided this experimental model using rabbits was found suitable for long term CAPD studies.