Principles ofbreeding, maintaining and working with diabetic and non-diabetic BB/Wor-rats

Abstract

The background for the development of the BB/Wor-rat as a model to be used in the diabetes research is described. The most essential pathological and clinical aspects are also described. Experiences from the breeding and therapy are refered and results on lowering the incidence by treatment with cyclosporine-A and injections of immunocompetent spleen cells are given.