Local chemical irritation on mucosal surface, measured colorimetrieally on the frog palate model

Abstract

The effect of chemicals. toxins. allergens etc. on biological tissues are usually evaluated in microscopes as well as objective by giving different scores for different signs. When visual evaluation is used, the investigations may see each colour or
each sign in a different manner. Experiments were conducted in order to evaluate the possibility of measuring the irritation and mucus secretion caused by irritation by the mean of digitalizing the colour density in the palatal mucosa] membrane
of the frog. using a eolorimcter. Increased redness 0n the mucosal surface was seen as increased colour density, giving high values. whereas increased mueus secretion resulted in decrease in colour density. giving lower values than seen for normal
mucosa.