Technical note: Technique for administering drugs to the brain and bypassing the blood-brain-barrier
Drug delivery to the olfactory region may result in absorption to the brain without entering the bloodstream thus bypassing the blood —brain barrier A simpie technique15 described for administering drugs to the olfactory region in mice and
rats. During anaesthesia with i.p. pentobarbital administration, the drug is administered directly to the olfactory region in the nasal cavity, through the incisive duct, using a modified needle-pipette tip device. After the drug delivery, samples may
be collected from the cerebrospinal fluid or from various regions ofthe brain.