Effect of mixed administration of selenium and fenitrothion on pathomorphological pattern in internal organs in rats

Authors

  • Josef Szarek Department of Forensic Veterinary Medicine and Veterinary Medicine Administration
  • Arkadiusz Zasadowski Department of Veterinary and Environmental Toxicology, Faculty of Veterinary Medicine, Olsztyn University of Agriculture and Technology
  • Jacek Fabczak Department of Forensic Veterinary Medicine and Veterinary Medicine Administration
  • Darius Barski Department of Veterinary and Environmental Toxicology, Faculty of Veterinary Medicine, Olsztyn University of Agriculture and Technology

DOI:

https://doi.org/10.23675/sjlas.v22i4.780

Abstract

Mixed intoxication in rats with sodium selenite (0.40 ppm) and fenitrothion (40 mg/kg bm.) resulted in pathomorphological changes in stomach, intestine, spleen and cardiac muscle which were more intense than in Cases when the mentioned
compounds were administered singly. When a lower dose of selenium (0.08 ppm) together with fenitrothion (40 mg/kg b.m.) was used there was a decrease of disorders in examined organs.
Moreover, the changes were even less intense than when selenium (0.40 ppm) or fenitrothion (40 mg/kg h.m.) were administered as a single toxicant.
Thus, it was concluded that selenium at a dose of 0.08 ppm protected the rats by limiting the toxic activity of Ienitrothion.

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Published

01.12.1995

How to Cite

Szarek, J., Zasadowski, A., Fabczak, J., & Barski, D. (1995). Effect of mixed administration of selenium and fenitrothion on pathomorphological pattern in internal organs in rats. Scandinavian Journal of Laboratory Animal Science, 22(4). https://doi.org/10.23675/sjlas.v22i4.780

Issue

Vol. 22 No. 4 (1995)

Section

Articles