Application of a mouse-mastitis model for evaluation of antigen vaccines against Staphylococcus aureus-induced mastitis

Abstract

The BSVS-mouse mastitis model has been shown to largely mimic boyine intramammary infection (mastitis), where bacteria penetrate through the teat canal, teat cisterns and establish in the mammary glands. The model enables study of the
onset of infection and histopathological changes occurring during the development at infection in the mammary glands. Mice were immunised with recombinant antigen vaccines and thereafter were challenged with S. aureus. Vaccine-evoked serumantibody responses and protection were determined. This study demonstrates the relevance of the BSVS~mouse mastitis model for evaluation of recombinant surface-antigen vaccines against S. aureus-indueed mastitis.