The Effect of Moclobemide, Reversible Inhibitor of Monoamine Oxidase-A, on the Alcoholized Rat Brain

Abstract

This experiment was carried out to demonstrate the effect of moclobemide on the brains of rats fed on a diet containing alcohol. Thirty male rats, 200-250 g were used. Rats were fed with a diet (milk) containing ethyl alcohol (10%) in the alcohol-only treated group and were injected subcutaneously with moclobemide (30 mg/kg) in the alcohol + moclobemide treated group daily for 21 days. It is found that the serum ethanol level in the aicohol + moclobemide treated group was significantly higher than in alcohol-only treated group at the end of the experiment. Electron microscopic examination revealed more prominent neurotoxicity in the alcohol tmoclobemide treated group than in alcohol-only treated group. We concluded that moclobemide decreases the elimination of ethanol, However, more studies are needed to demonstrate its mechanism.