Possible routes of contamination of laboratory rodents kept in research facilities

Abstract

The risk of introducing pathogens or other unwanted microorganisms into research colonies of rodents is higher than into breeding colonies. To achieve a realistic control of infectious agents, a simultaneous attack should be made on all possible
routes of contamination. In this context, the importance of an adequate management system in addition to a proper design of the animal facility is stressed. Animals are considered the most important factor. As most infections in rodents are subclinical, exclusion of infection can only be achieved by appropriate diagnostic methods. Further, biological materials which have been passaged in rodents are an important source of microorganisms. They can be stored frozen for many years without any loss of infectivity. Moreover, rodents are at risk from people who frequently act as carriers when they have been in contact with infected animals or contaminated equipment. In addition, the importance of vermin and other risk factors like food, water, and air is briefly discussed.