Severe bradycardia and hypotension in anaesthetized pigs: Possible interaction between octreotide, xylazine, and atropine: A case series

Abstract

Pigs are common animal models in diabetes research. Streptozotocin-induced destruction of pancreatic β-cells is used to induce diabetes in conscious pigs. However, in short-term non-recovery experiments, suppression of endogenous insulin secretion can be faster and more easily achieved with somatostatin analogues. We report a series of severe and unexpected episodes of severe bradycardia in eight pigs during non-recovery experiments with the original aim of investigating the pharmacokinetics and pharmacodynamics of intraperitoneal hormone delivery. The adverse events occurred four to five hours into the experiments, and we believe that they were caused by an interaction between the somatostatin analogue octreotide, and the sedative drug xylazine and that atropine delayed the time of occurrence.